Anti-Cleaved PARP 单克隆抗体-抗体-抗体-生物在线
北京索莱宝科技有限公司
Anti-Cleaved PARP 单克隆抗体

Anti-Cleaved PARP 单克隆抗体

商家询价

产品名称: Anti-Cleaved PARP 单克隆抗体

英文名称: Anti-Cleaved PARP Monoclonal Antibody

产品编号: K000215M

产品价格: null

产品产地: 北京

品牌商标: Solarbio

更新时间: 2025-02-08T13:37:52

使用范围: WB IHC

北京索莱宝科技有限公司
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Anti-Cleaved PARP Monoclonal Antibody

品牌:solarbio | 货号:K000215M
英文名称Anti-Cleaved PARP Monoclonal Antibody
宿主Mouse
别名ADPRT;ADPRT1;ADPRT1;ARTD1;pADPRT-1;PARP;PARP-1;PPOL
应用WB IHC
稀释比例WB 1:2000-5000. IHC 1:200-500.
交叉反应Human
蛋白分子量116/89kDa
Gene ID142
保存Store at -20°C. Avoid freeze / thaw cycles.
储存液Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
纯化方法Saturated ammonium sulfate precipitation
亚型IgG1
免疫原Synthetic Peptide
性状液体
Public Immunogen RangeSynthetic Peptide
Subcellular LocationsNucleus nucleolus
Swiss ProtP09874
克隆号Mix
克隆类型Monoclonal Antibody
背景资料Poly [ADP-ribose] polymerase 1 (PARP-1) also known as NAD+ ADP-ribosyltransferase 1 or poly[ADP-ribose] synthase 1 is an enzyme that in humans is encoded by the PARP1 gene. PARP1 has a role in repair of single-stranded DNA (ssDNA) breaks. Knocking down intracellular PARP1 levels with siRNA or inhibiting PARP1 activity with small molecules reduces repair of ssDNA breaks. In the absence of PARP1, when these breaks are encountered during DNA replication, the replication fork stalls, and double-strand DNA (dsDNA) breaks accumulate.