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Anti-Cleaved PARP 单克隆抗体
产品名称: Anti-Cleaved PARP 单克隆抗体
英文名称: Anti-Cleaved PARP Monoclonal Antibody
产品编号: K000215M
产品价格: null
产品产地: 北京
品牌商标: Solarbio
更新时间: 2025-02-08T13:37:52
使用范围: WB IHC
北京索莱宝科技有限公司
- 联系人 : 索莱宝-龚思雨
- 地址 : 北京市通州区中关村科技园区通州园金桥科技产业基地景盛南四街15号85A三层
- 邮编 : 101102
- 所在区域 : 北京
- 电话 : 178****1073 点击查看
- 传真 : 点击查看
- 邮箱 : 3193328036@qq.com
- 二维码 : 点击查看
Anti-Cleaved PARP Monoclonal Antibody
品牌:solarbio | 货号:K000215M
英文名称 | Anti-Cleaved PARP Monoclonal Antibody |
---|---|
宿主 | Mouse |
别名 | ADPRT;ADPRT1;ADPRT1;ARTD1;pADPRT-1;PARP;PARP-1;PPOL |
应用 | WB IHC |
稀释比例 | WB 1:2000-5000. IHC 1:200-500. |
交叉反应 | Human |
蛋白分子量 | 116/89kDa |
Gene ID | 142 |
保存 | Store at -20°C. Avoid freeze / thaw cycles. |
储存液 | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
纯化方法 | Saturated ammonium sulfate precipitation |
亚型 | IgG1 |
免疫原 | Synthetic Peptide |
性状 | 液体 |
Public Immunogen Range | Synthetic Peptide |
Subcellular Locations | Nucleus nucleolus |
Swiss Prot | P09874 |
克隆号 | Mix |
克隆类型 | Monoclonal Antibody |
背景资料 | Poly [ADP-ribose] polymerase 1 (PARP-1) also known as NAD+ ADP-ribosyltransferase 1 or poly[ADP-ribose] synthase 1 is an enzyme that in humans is encoded by the PARP1 gene. PARP1 has a role in repair of single-stranded DNA (ssDNA) breaks. Knocking down intracellular PARP1 levels with siRNA or inhibiting PARP1 activity with small molecules reduces repair of ssDNA breaks. In the absence of PARP1, when these breaks are encountered during DNA replication, the replication fork stalls, and double-strand DNA (dsDNA) breaks accumulate. |